Streptonigrin
Cat. No.：YN310509
| 产品名称: | Streptonigrin |
| CAS No.: | 3930-19-6 |
| Chemical Name: | (4R)-5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic acid |
| Synonyms: | Bruneomycin |
| 分子量: | 506.46434 |
| 分子式: | C25H22N4O8 |
| SMILES: | NC1=C(OC)C(C(C=CC(C2=C(N)C(C3=CC=C(OC)C(OC)=C3O)=C(C)C(C(O)=O)=N2)=N4)=C4C1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Streptonigrin (Bruneomycin) 是由链霉菌 (Streptomyces flocculus) 产生的一种天然产物，具有抗肿瘤和抗菌活性。Streptonigrin 可作为pan-PAD抑制剂，抑制PAD1，PAD2，PAD3和PAD4的IC50分别为 48.3±34.2 μM，26.1±0.3 μM，0.43±0.03 μM 和 2.5±0.4 μM。 |
| IC50和靶点: | |
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Yamashita, Y., Kawada, S., Fujii, N., et al.Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrinCancer Res.50(18),5841-5844(1990)
Levine, M., and Borthwick, M.The action of streptonigrin on bacterial DNA metabolism and on induction of phage production in lysogenic bacteriaVirology21(4),568-574(1963)
Yeowell, H.N., and White, J.R.Iron requirement in the bactericidal mechanism of streptonigrinAntimicrob. Agents Chemother.22(6),961-968(1982)
Beall, H.D., Liu, Y., Siegel, D., et al.Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrinBiochem. Pharmacol.51(5),645-652(1996)
Cohen, M.M., Shaw, M.W., and Craig, A.P.The effects of streptonigrin on cultured human leukocytesProc. Natl. Acad. Sci. USA50(1),16-24(1963)
McBride, T.J., Oleson, J.J., and Woolf, D.The activity of streptonigrin against the Rauscher murine leukemia virus in vivoCancer Res.26(4),727-732(1966)
