MS37452
Cat. No.：YN310512
CAS No. ：423748-02-1
| 产品名称: | MS37452 |
| CAS No.: | 423748-02-1 |
| Chemical Name: | 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone |
| Synonyms: | MS37452 |
| 分子量: | 398.5 |
| 分子式: | C22H26N2O5 |
| SMILES: | COC1=CC=CC(C(N2CCN(C(COC3=CC(C)=CC=C3)=O)CC2)=O)=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MS37452 是一种有效的CBX7chromodomain 与H3K27me3结合的抑制剂，Kd为 27.7 μM。MS37452 可以通过置换 CBX7 与前列腺癌细胞中INK4A/ARF基因座的结合来抑制多梳抑制复合物靶基因 p16/CDKN2A 的转录。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ren, C., Morohashi, K., Plotnikov, A.N., et al.Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomainChem. Biol.22,161-168(2015)
