MeBIO
Cat. No.：YN290799
CAS No. ：667463-95-8
| 产品名称: | MeBIO |
| CAS No.: | 667463-95-8 |
| Chemical Name: | (3Z)-6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-1-methyl-2H-indol-2-one |
| Synonyms: | |
| 分子量: | 370.2 |
| 分子式: | C17H12BrN3O2 |
| SMILES: | O/N=C(C1=CC=CC=C1N2)/C2=C3C(N(C)C4=CC(Br)=CC=C4/3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MeBIO 是一种有效的AhR激动剂，其IC50分别为 44 μM (GSK-3) 和 55 μM (CDK1/cyclin b). MeBIO 对GSK-3β不起作用。 |
| IC50和靶点: | [{name:"GSK-3:44 μM (IC50)"},{name: "Cdk1/cyclin B:55 μM (IC50)"},{name: "Cdk5/p25:>100 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Polychronopoulos, P., Magiatis, P., Skaltsounis, A.L., et al.Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinasesJ. Med. Chem.47(4),935-946(2004)
Meijer, L., Skaltsounis, A.L., Magiatis, P., et al.GSK-3-selective inhibitors derived from tyrian purple indirubinsChem. Biol.10(12),1255-1266(2003)
Knockaert, M., Blondel, M., Bach, S., et al.Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubinsOncogene23(25),4400-4412(2004)
