Teleocidin A1
Cat. No.：YN310520
| 产品名称: | Teleocidin A1 |
| CAS No.: | 70497-14-2 |
| Chemical Name: | (2S,5S)-9-[(1R)-1-ethenyl-1,5-dimethyl-4-hexen-1-yl]-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one |
| Synonyms: | Lyngbyatoxin A |
| 分子量: | 437.61758 |
| 分子式: | C27H39N3O2 |
| SMILES: | O=C([C@@H](C(C)C)N1C)N[C@H](CO)CC2=CNC3=C([C@](C=C)(C)CC/C=C(C)/C)C=CC1=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Teleocidin A1 (Lyngbyatoxin A) 是一种剧毒皮肤刺激物，是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1 对 HeLa 癌细胞具有抗增殖活性 (IC50=9.2 nM)。 |
| IC50和靶点: | |
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Sakai, S.-I., Hitotsuyanagi, Y., Aimi, N., et al.Absolute configuration of lyngbyatoxin A (teleocidin A-1) and teleocidin A-2Tetrahedron Lett.27(43),5219-5220(1986)
Fujiki, H., and Sugimura, T.New classes of tumor promoters: Teleocidin, aplysiatoxin, and palytoxinAdv. Cancer Res.49,223-264(1987)
Sakamoto, H., Terada, M., Fujiki, H., et al.Stimulation of prostaglandin production and choline turnover in HeLa cells by lyngbyatoxin A and dihydroteleocidin BBiochem. Biophys. Res. Commun.102(1),100-107(1981)
Yu, F., Li, M., Xu, C., et al.Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleDBiochem. J.473(23),4385-4397(2016)
