Elacridar
Cat. No.：YN360711
CAS No. ：143664-11-3
| 产品名称: | Elacridar |
| CAS No.: | 143664-11-3 |
| Chemical Name: | N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide |
| Synonyms: | GF120918; GW0918; GG918; GW120918 |
| 分子量: | 563.64 |
| 分子式: | C₃₄H₃₃N₃O₅ |
| SMILES: | O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elacridar (GF120918) 是一种有效的 P-糖蛋白 (P-glycoprotein) 和BCRP的抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Witherspoon, S.M., Emerson, D.L., Kerr, B.M., et al.Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918Clin. Cancer Res.2(1),7-12(1996)
Letrent, S.P., Pollack, G.M., Brouwer, K.R., et al.Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the ratDrug Metab. Dispos.27(7),827-834(1999)
de Bruin, M., Miyake, K., Litman, T., et al.Reversal of resistance by GF120918 in cell lines expressing the ABC halftransporter, MXRCancer Lett.146(2),117-126(1999)
Jonker, J.W., Smit, J.W., Brinkhuis, R.F., et al.Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecanJ. Natl. Cancer Inst.92(20),1651-1656(2000)
