Ceftaroline fosamil
Cat. No.：YN250593
CAS No. ：400827-46-5
规格
价格(RMB)
库存
| 产品名称: | Ceftaroline fosamil |
| CAS No.: | 400827-46-5 |
| Chemical Name: | 4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-pyridinium, monoacetate |
| Synonyms: | TAK-599; PPI0903 |
| 分子量: | 744.74 |
| 分子式: | C₂₄H₂₅N₈O₁₀PS₄ |
| SMILES: | O=C1[C@@H](NC(/C(C2=NSC(NP(O)(O)=O)=N2)=N\OCC)=O)[C@@]3([H])SCC(SC4=NC(C5=CC=[N+](C)C=C5)=CS4)=C(C(O)=O)N13.CC([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceftaroline fosamil (TAK-599) 是一种能抗革兰氏阳性病原体包括耐甲氧西林金黄色葡萄球菌 (MRSA) 的头孢菌素。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ishikawa, T., Matsunaga, N., Tawada, H., et al.TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological propertiesBioorg. Med. Chem.11(11),2427-2437(2003)
Andes, D., and Craig, W.A.Pharmacodynamics of a new cephalosporin, PPI-0903 (TAK-599), active against methicillin-resistant Staphylococcus aureus in murine thigh and lung infection models: Identification of an in vivo pharmacokinetic-pharmacodynamic targetAntimicrob. Agents Chemother.50(4),1376-1383(2006)
Iizawa, Y., Nagai, J., Ishikawa, T., et al.In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599J. Infect. Chemother.10(3),146-156(2004)
