Clindamycin
Cat. No.：YN251322
CAS No. ：18323-44-9
| 产品名称: | Clindamycin |
| CAS No.: | 18323-44-9 |
| Chemical Name: | methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside |
| Synonyms: | Sobelin,Clinimycin,Chlolincocin,克林霉素 |
| 分子量: | 424.98 |
| 分子式: | C₁₈H₃₃ClN₂O₅S |
| SMILES: | CN(C[C@H](CCC)C1)[C@@H]1C(N[C@@]([C@@H](Cl)C)([H])[C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clindamycin 是一种口服有效的蛋白质合成抑制剂，其具有以亚抑制浓度 (sub-MICs) 在金黄色葡萄球菌中毒力因子表达的能力。Clindamycin 的抗性是由 50S 核糖体亚基 (23S rRNA) 中抗生素结合位点的酶促甲基化产生。Clindamycin 降低杀白细胞毒素 (PVL)，毒性休克-葡萄球菌毒素 (TSST-1) 或 α-溶血素 (Hla) 的产生。 |
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Spížek, J., and Řezanka, T.Lincomycin, clindamycin and their applicationsAppl. Microbiol. Biotechnol.64(4),455-464(2004)
Dahl, E.L., and Rosenthal, P.J.Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplastAntimicrob. Agents Chemother.51(10),3485-3490(2007)
Karlström, Å., Boyd, K.L., English, B.K., et al.Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenzaJ. Infect. Dis.199(3),311-319(2009)
