Icatibant acetate
Cat. No.：YN320387
CAS No. ：138614-30-9
| 产品名称: | Icatibant acetate |
| CAS No.: | 138614-30-9 |
| Chemical Name: | D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-L-arginine, acetate |
| Synonyms: | HOE 140 acetate |
| 分子量: | 1364.57 |
| 分子式: | C₆₁H₉₃N₁₉O₁₅S |
| SMILES: | CC(O)=O.OC[C@H](NC([C@@H](NC(CNC([C@H]1N(C([C@H]2N(C(CNC(CCCCNC(N)=N)=O)=O)CCC2)=O)CCC1)=O)=O)CC1SC=CC=1)=O)C(N1C(C(N2[C@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)C[C@H]3[C@@H]2CCCC3)=O)CC2=C(C=CC=C2)C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Icatibant acetate (HOE-140 acetate) 是有效的，特异的缓激肽 B2 受体拮抗剂，IC50和Ki值分别为 1.07 nM和 0.798 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hock, F.J., Wirth, K., Albus, U., et al.Hoe 140 a new potent and long acting bradykinin-antagonist: In vitro studiesBr. J. Pharmacol.102(3),769-773(1991)
Han, E.D., MacFarlane, R.C., Mulligan, A.N., et al.Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptorJ. Clin. Invest.109(8),1057-1063(2002)
