RN486
Cat. No.：YN440372
CAS No. ：1242156-23-5
规格
价格(RMB)
库存
| 产品名称: | RN486 |
| CAS No.: | 1242156-23-5 |
| Chemical Name: | 6-cyclopropyl-2-[3-[1,6-dihydro-1-methyl-5-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-(hydroxymethyl)phenyl]-8-fluoro-1(2H)-isoquinolinone |
| Synonyms: | RN486; RN-486; RN 486 |
| 分子量: | 606.69 |
| 分子式: | C₃₅H₃₅FN₆O₃ |
| SMILES: | O=C1C(NC2=CC=C(N3CCN(C)CC3)C=N2)=CC(C4=CC=CC(N5C=CC(C=C(C6CC6)C=C7F)=C7C5=O)=C4CO)=CN1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RN486 是一种有效的，选择性的，具有口服活性的Btk抑制剂，IC50为 4.0 nM，Kd为 0.31 nM，对其他激酶的活性较低。RN486 可用于类风湿关节炎和系统性红斑狼疮的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Xu, D., Kim, Y., Postelnek, J., et al.RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodentsJ. Pharmacol. Exp. Ther.341(1),90-103(2012)
