YM-58483
Cat. No.：YN360060
CAS No. ：223499-30-7
| 产品名称: | YM-58483 |
| CAS No.: | 223499-30-7 |
| Chemical Name: | N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide |
| Synonyms: | BTP2 |
| 分子量: | 421.32 |
| 分子式: | C₁₅H₉F₆N₅OS |
| SMILES: | O=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YM-58483 是一种有效的CRAC channels抑制剂，能够抑制 Ca2+信号。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ishikawa, J., Ohga, K., Yoshino, T., et al.A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytesJ. Immunol.170(9),4441-4449(2003)
Yoshino, T., Ishikawa, J., Ohga, K., et al.YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal modelsEur. J. Pharmacol.560(2-3),225-233(2007)
