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Navarixin

Cat. No.:473727-83-2

  • CAS No. :473727-83-2

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    • 参考文献
    • 产品名称: Navarixin
      CAS No.: 473727-83-2
      Chemical Name:
      Synonyms:SCH 527123; MK-7123
      分子量:397.42
      分子式:C₂₁H₂₃N₃O₅
      SMILES:O=C1C(C(NC2=CC=CC(C(N(C)C)=O)=C2O)=C1N[C@H](CC)C3=CC=C(O3)C)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Gonsiorek, W., Fan, X., Hesk, D., et al.Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.J. Pharmacol. Exp. Ther.322(2),477-485(2007)', 'Chapman, R.W., Minnicozzi, M., Celly, C.S., et al.A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammationJ. Pharmacol. Exp. Ther.322(2),486-493(2007)', 'Ning, Y., Labonte, M.J., Zhang, W., et al.The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer modelsMol. Cancer Ther.11(6),1353-1364(2012)
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