Lomeguatrib

Cat. No.：192441-08-0

CAS No. ：192441-08-0

产品名称:	Lomeguatrib
CAS No.:	192441-08-0
Chemical Name:
Synonyms:	PaTrin-2
分子量:	326.17
分子式:	C₁₀H₈BrN₅OS
SMILES:	NC1=NC(OCC2=CC(Br)=CS2)=C3N=CNC3=N1
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

McMurry, T.B.H.MGMT inhibitors-the Trinity College-Paterson Institute experience, a chemist's perceptionDNA Repair6(8),1161-1169(2007)", 'Clemons, M., Kelly, J., Watson, A.J., et al.O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenograftsBr. J. Cancer93(10),1152-1156(2005)', 'Marchesi, F., Turriziani, M., Tortorelli, G., et al.Triazene compounds: Mechanism of action and related DNA repair systemsPharmacol. Res.56(4),275-287(2007)', 'Ranson, M., Middleton, M.R., Bridgewater, J., et al.Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: Phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumorsClin. Cancer Res.12(5),1577-1584(2006)', 'Watson, A.J., Sabharwal, A., Thorncroft, M., et al.Tumor O6-methylguanine-DNA methyltransferase inactivation by oral lomeguatribClin. Cancer Res.16(2),743-749(2010)