L-741626
Cat. No.：YN1730011
CAS No. ：81226-60-0
| 产品名称: | L-741626 |
| CAS No.: | 81226-60-0 |
| Chemical Name: | 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol |
| Synonyms: | 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole |
| 分子量: | 340.85 |
| 分子式: | C₂₀H₂₁ClN₂O |
| SMILES: | OC1(C2=CC=C(Cl)C=C2)CCN(CC3=CNC4=C3C=CC=C4)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-741626 是一种选择性D2多巴胺受体拮抗剂，对人 D2、D3 和 D4 受体的Ki值分别为 2.4、100 和 220 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kulagowski, J.J., Broughton, H.B., Curtis, N.R., et al.3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D4 receptorJ. Med. Chem.39(10),1941-1942(1996)
Millan, M.J., Gobert, A., Newman-Tancredi, A., et al.S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626J. Pharmacol. Exp. Ther.293(3),1048-1062(2000)
Grundt, P., Husband, S.L., Luedtke, R.R., et al.Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SARBioorg. Med. Chem. Lett.17(3),745-749(2007)
Pillai, G., Brown, N.A., McAllister, G., et al.Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectivelyNeuropharmacology37(8),983-987(1998)
Millan, M.J., Dekeyne, A., Rivet, J.M., et al.S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626J. Pharmacol. Exp. Ther.293(3),1063-1073(2000)
