SB-277011 dihydrochloride
Cat. No.：YN1730026
| 产品名称: | SB-277011 dihydrochloride |
| CAS No.: | 1226917-67-4 |
| Chemical Name: | N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide, dihydrochloride |
| Synonyms: | SB-277011A dihydrochloride |
| 分子量: | 511.49 |
| 分子式: | C₂₈H₃₂Cl₂N₄O |
| SMILES: | O=C(C1=CC=NC2=CC=CC=C12)N[C@H]3CC[C@H](CCN4CC5=C(C=C(C#N)C=C5)CC4)CC3.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-277011 dihydrochloride (SB-277011A dihydrochloride) 是一种有效的，选择性的，可口服的，可透过血脑屏障的dopamine D3受体拮抗剂，对 D3，D2，5-HT1B和 5-HT1D受体的pKi值分别为 8.0，6.0，<5.2 和 5.9。 |
| IC50和靶点: | |
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Stemp, G., Ashmeade, T., Branch, C.L., et al.Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the ratJ. Med. Chem.43(9),1878-1885(2000)
Reavill, C., Taylor, S.G., Wood, M.D., et al.Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-AJ. Pharmacol. Exp. Ther.294(3),1154-1165(2000)
Heidbreder, C.A., Gardner, E.L., Xi, Z.-X., et al.The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidenceBrain Res.Rev.49(1),77-105(2005)
Carcinella, S., Drui, G., Boulet, S., et al.Implication of dopamine D3 receptor activation in the reversion of Parkinson's disease-related motivational deficitsTransl. Psychiatry4(6),e401(2014)
