Longdaysin
Cat. No.：YN350183
CAS No. ：1353867-91-0
| 产品名称: | Longdaysin |
| CAS No.: | 1353867-91-0 |
| Chemical Name: | 9-(1-methylethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]-9H-purin-6-amine |
| Synonyms: | Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. |
| 分子量: | 335.33 |
| 分子式: | C₁₆H₁₆F₃N₅ |
| SMILES: | FC(F)(F)C1=CC=CC(CNC2=NC=NC3=C2N=CN3C(C)C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Longdaysin 是Wnt/β-catenin信号通路的抑制剂，通过阻断CK1δ/ε依赖性 Wnt 信号通路发挥抗肿瘤作用。Longdaysin 抑制CK1α，CK1δ，CDK7，ERK2， 对 CK1α，CK1δ，CDK7，ERK2 的IC50值分别为 5.6 µM，8.8 µM，29 µM，52 µM。 |
| IC50和靶点: | [{name:"CKIα:5.6 μM (IC50)"},{name: "CKIδ:8.8 μM (IC50)"},{name: "CDK7:29 μM (IC50)"},{name: "ERK2:52 μM (IC50)"}] |
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