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Relugolix

Cat. No.：737789-87-6

  • CAS No. ：737789-87-6

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    • 产品名称: Relugolix
      CAS No.: 737789-87-6
      Chemical Name:
      Synonyms:瑞卢戈利; TAK-385
      分子量:623.63
      分子式:C₂₉H₂₇F₂N₇O₅S
      SMILES:O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)C)C(C(N3C4=NN=C(OC)C=C4)=O)=C2N(CC5=C(F)C=CC=C5F)C3=O)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Miwa, K., Hitaka, T., Imada, T., et al.Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptorJ. Med. Chem.54(14),4998-5012(2011)', 'Nakata, D., Masaki, T., Tanaka, A., et al.Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: Studies in human GnRH receptor knock-in miceEur. J. Pharmacol.723,167-174(2014)
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