Elagolix sodium
Cat. No.：YN320860
CAS No. ：832720-36-2
规格
价格(RMB)
库存
| 产品名称: | Elagolix sodium |
| CAS No.: | 832720-36-2 |
| Chemical Name: | 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]-butanoic acid, monosodium salt |
| Synonyms: | NBI-56418 sodium |
| 分子量: | 653.57 |
| 分子式: | C₃₂H₂₉F₅N₃NaO₅ |
| SMILES: | O=C(O[Na])CCCN[C@H](C1=CC=CC=C1)CN(C(N(CC2=C(C(F)(F)F)C=CC=C2F)C(C)=C3C4=CC=CC(OC)=C4F)=O)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elagolix sodium 是一种人的GnRH受体 (GnRHR) 拮抗剂，其IC50和Ki值分别为 0.25 和 3.7 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chen, D., Wu, D., Guo, Z., et al.Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptorJ. Med. Chem.51(23),7478-7485(2008)
