MBX-2982
Cat. No.：YN320961
CAS No. ：1037792-44-1
| 产品名称: | MBX-2982 |
| CAS No.: | 1037792-44-1 |
| Chemical Name: | 5-ethyl-2-[4-[4-[[4-(1H-tetrazol-1-yl)phenoxy]methyl]-2-thiazolyl]-1-piperidinyl]-pyrimidine |
| Synonyms: | MBX 2982;5-Ethyl-2-[4-[4-[[[4-(1H-tetrazol-1-yl)phenyl]oxy]methyl]thiazol-2-yl]piperidin-1-yl]pyrimidine;MBX-2982;2-[1-(5-Ethylpyrimidin-2-yl)-4-piperidyl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]thiazole;2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tet |
| 分子量: | 448.54 |
| 分子式: | C₂₂H₂₄N₈OS |
| SMILES: | CCC1=CN=C(N2CCC(C3=NC(COC4=CC=C(N5N=NN=C5)C=C4)=CS3)CC2)N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MBX-2982 是一种口服选择性的 G 蛋白偶联受体 119 (GPR119) 激动剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Yang, J.W., Kim, H.S., Im, J.H., et al.GPR119: A promising target for nonalcoholic fatty liver diseaseFASEB J.30(1),324-335(2016)
Lan, H., Lin, H.V., Wang, C.F., et al.Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathwaysBr. J. Pharmacol.165(8),2799-2807(2012)
Spasov, A.A., Kosolapov, V.A., Babkov, D.A., et al.Effect of GRP119 receptor agonist, compound MBX-2982, on activity of human glucokinaseBull. Exp. Biol. Med.163(5),695-698(2017)
