Ceralasertib
Cat. No.：YN420259
CAS No. ：1352226-88-0
规格
价格(RMB)
库存
| 产品名称: | Ceralasertib |
| CAS No.: | 1352226-88-0 |
| Chemical Name: | 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine |
| Synonyms: | AZD6738 |
| 分子量: | 412.51 |
| 分子式: | C₂₀H₂₄N₆O₂S |
| SMILES: | O=[S@@](C1(CC1)C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(N5CCOC[C@H]5C)=C2)(C)=N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceralasertib (AZD6738) 是有效地ATR激酶抑制剂，IC50值为 1 nM。 |
| IC50和靶点: | [{name:"ATR:1 nM (IC50)"},{name: "PI3Kδ:6.8 μM (IC50)"},{name: "DYRK:10.8 μM (IC50)"}] |
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| Solvent & Solubility: |
Vendetti, F.P., Lau, A., Schamus, S., et al.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivoOncotarget6(42),44289-44305(2015)
