Tonabersat

Cat. No.：175013-84-0

CAS No. ：175013-84-0

产品名称:	Tonabersat
CAS No.:	175013-84-0
Chemical Name:
Synonyms:	SB-220453
分子量:	391.82
分子式:	C₂₀H₁₉ClFNO₄
SMILES:	O[C@@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[C@@H]1NC(C3=CC(Cl)=C(F)C=C3)=O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Dahlöf , C.G.H., Hauge, A.W., and Olesen, J.Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: A double-blind, parallel-group, randomized study.Cephalalgia29 (Suppl 2),7-16(2009)', 'Damodaram, S., Thalakoti, S., Freeman, S.E., et al.Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signalingHeadache49(1),5-20(2009)', 'Kim, Y., Griffin, J.M., Nor, M.N.M., et al.Tonabersat prevents inflammatory damage in the central nervous system by blocking connexin43 hemichannelsNeurotherapeutics,(2017)', 'Durham, P.L., and Garrett, F.G.Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraineCephlalalgia29(Suppl 2),(2009)', 'Chan, W.N., Evans, J.M., Hadley, M.S., et al.Identification of (−)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agentBioorg. Med. Chem. Lett.9(2),285-290(1999)