Tonabersat
Cat. No.：YN300039
CAS No. ：175013-84-0
| 产品名称: | Tonabersat |
| CAS No.: | 175013-84-0 |
| Chemical Name: | N-[(3S,4S)-6-acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-3-chloro-4-fluoro-benzamide |
| Synonyms: | SB-220453 |
| 分子量: | 391.82 |
| 分子式: | C₂₀H₁₉ClFNO₄ |
| SMILES: | O[C@@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[C@@H]1NC(C3=CC(Cl)=C(F)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tonabersat (SB-220453) 是一种gap-junction调节剂。Tonabersat Tonabersat 预防中枢神经系统的炎症损伤。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dahlöf , C.G.H., Hauge, A.W., and Olesen, J.Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: A double-blind, parallel-group, randomized study.Cephalalgia29 (Suppl 2),7-16(2009)
Damodaram, S., Thalakoti, S., Freeman, S.E., et al.Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signalingHeadache49(1),5-20(2009)
Kim, Y., Griffin, J.M., Nor, M.N.M., et al.Tonabersat prevents inflammatory damage in the central nervous system by blocking connexin43 hemichannelsNeurotherapeutics,(2017)
Durham, P.L., and Garrett, F.G.Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraineCephlalalgia29(Suppl 2),(2009)
Chan, W.N., Evans, J.M., Hadley, M.S., et al.Identification of (−)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agentBioorg. Med. Chem. Lett.9(2),285-290(1999)
