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Islatravir

Cat. No.：865363-93-5

  • CAS No. ：865363-93-5

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    • 产品名称: Islatravir
      CAS No.: 865363-93-5
      Chemical Name:
      Synonyms:MK-8591
      分子量:293.25
      分子式:C₁₂H₁₂FN₅O₃
      SMILES:OC[C@]1(C#C)[C@H](C[C@H](N2C=NC3=C2N=C(F)N=C3N)O1)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Michailidis, E., Huber, A.D., Ryan, E.M., et al.4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanismsJ. Biol. Chem.289(35),24533-24548(2014)", "Markowitz, M., and Sarafianos, S.G.4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: A novel HIV-1 reverse transcriptase translocation inhibitorCurr. Opin. HIV AIDS13(4),294-299(2018)", "Kawamoto, A., Kodama, E., Sarafianos, S.G., et al.2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variantsInt. J. Biochem. Cell Biol.40(11),2410-2420(2008)", "Stoddart, C.A., Galkina, S.A., Joshi, P., et al.Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaqueAntimicrob. Agents Chemother.59(7),4190-4198(2015)
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