Q-VD-OPh
Cat. No.：YN250332
CAS No. ：1135695-98-5
| 产品名称: | Q-VD-OPh |
| CAS No.: | 1135695-98-5 |
| Chemical Name: | (3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid |
| Synonyms: | QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone |
| 分子量: | 513.49 |
| 分子式: | C₂₆H₂₅F₂N₃O₆ |
| SMILES: | O=C(O)C[C@H](NC([C@@H](NC(C1=NC2=CC=CC=C2C=C1)=O)C(C)C)=O)C(COC3=C(F)C=CC=C3F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Q-VD-OPh 是一种不可逆的泛胱天蛋白酶 (caspase) 抑制剂，具有高效的抗凋亡能力。抑制胱天蛋白酶 7 的IC50值别为 48 nM，抑制胱天蛋白酶 1，3，8，9，10，12 的IC50值在 25-400 nM 之间。Q-VD-OPh 可抑制HIV感染。Q-VD-OPh 能透过血脑屏障。 |
| IC50和靶点: | [{name:"Caspase-3:25-400 nM (IC50)"},{name: "Caspase-7:48 nM (IC50)"},{name: "Caspase-1:25-400 nM (IC50)"},{name: "Caspase-8:25-400 nM (IC50)"},{name: "Caspase-9:25-400 nM (IC50)"},{name: "Caspase-10:25-400 nM (IC50)"},{name: "Caspase-12:25-400 nM (IC50)"}] |
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Caserta, T.M., Smith, A.N., Gultice, A.D., et al.Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic propertiesApoptosis8(4),345-352(2003)
Kuzelová, K., Grebenová, D., and Brodská, B.Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processesJ. Cell. Biochem.112(11),3334-3342(2011)
Renolleau, S., Fau, S., Goyenvalle, C., et al.Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: A role for genderJ. Neurochem.100(4),1062-1071(2007)
Braun, J.S., Prass, K., Dirnagl, U., et al.Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPHExp. Neurol.206(2),183-191(2007)
Chen-Deutsch, X., Kutner, A., Harrison, J.S., et al.The pan-caspase inhibitor QVD has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cellsLeuk. Res.36(7),884-888(2012)
