Apelin-36(human)
Cat. No.：YN251818
| 产品名称: | Apelin-36(human) |
| CAS No.: | 252642-12-9 |
| Chemical Name: | L-leucyl-L-valyl-L-glutaminyl-L-prolyl-L-arginylglycyl-L-seryl-L-arginyl-L-asparaginylglycyl-L-prolylglycyl-L-prolyl-L-tryptophyl-L-glutaminylglycylglycyl-L-arginyl-L-arginyl-L-lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arg |
| Synonyms: | LVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF |
| 分子量: | 4195.83 |
| 分子式: | C₁₈₄H₂₉₇N₆₉O₄₃S |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apelin-36(human) 是一种内源性孤儿 G 蛋白偶联受体APJ激动剂，EC50为 20 nM。Apelin-36(human) 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) 与两种主要的生物活性有关：心血管和代谢。Apelin-36(human) 抑制HIV-1和HIV-2进入表达 APJ 的 NP2/CD4 细胞。 |
| IC50和靶点: | |
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Lee, D.K., Cheng, R., Nguyen, T., et al.Characterization of apelin, the ligand for the APJ receptorJ. Neurochem.74(1),34-41(2000)
Kleinz, M.J., and Davenport, A.P.Emerging roles or apelin in biology and medicinePharmacol. Ther.107(2),198-211(2005)
Tatemoto, K., Hosoya, M., Habata, Y., et al.Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptorBiochem. Biophys. Res. Commun.251(2),471-476(1998)
Zou, M.X., Liu, H.Y., Haraguchi, Y., et al.Apelin peptides block the entry of human immunodeficiency virus (HIV)FEBS Lett.473(1),15-18(2000)
