Dapivirine
Cat. No.：YN250582
CAS No. ：244767-67-7
| 产品名称: | Dapivirine |
| CAS No.: | 244767-67-7 |
| Chemical Name: | 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]-benzonitrile |
| Synonyms: | 达匹维林; TMC120; R147681 |
| 分子量: | 329.40 |
| 分子式: | C₂₀H₁₉N₅ |
| SMILES: | CC1=CC(C)=CC(C)=C1NC2=CC=NC(NC3=CC=C(C#N)C=C3)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dapivirine (TMC120) 是二芳基嘧啶 (DAPY) 的原型，是具有口服活性的非核苷类逆转录酶抑制剂(NRTI)。Dapivirine (TMC120) 可直接与HIV的逆转录酶结合。Dapivirine (TMC120)调节自噬并诱导 Akt、Bad 和 SAPK/JNK 的激活。 |
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Herrewege, Y.V., Michiels, J., Roey, J.V., et al.In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicidesAntimicrob. Agents Chemother.48(1),337-339(2004)
Sluis-Cremer, N., and Tachedjian, G.Mechanisms of inhibition of HIV replication by nonnucleoside reverse transcriptase inhibitorsVirus Res.134(1-2),147-156(2008)
