Fumagillin
Cat. No.：YN251127
CAS No. ：23110-15-8
| 产品名称: | Fumagillin |
| CAS No.: | 23110-15-8 |
| Chemical Name: | 2E,4E,6E,8E-decatetraenedioic acid, 1-[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester |
| Synonyms: | 烟曲霉素; Amebacilin; NSC9168 |
| 分子量: | 458.54 |
| 分子式: | C₂₆H₃₄O₇ |
| SMILES: | C[C@]1([C@@H](CC=C(C)C)O1)[C@]([C@@H]2OC)([H])[C@]3(CC[C@H]2OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)CO3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fumagillin(NSC9168)由烟曲霉菌中提取，有抗抗阿米巴活性。Fumagillin 通过抑制HIV-1 viral protein R活性来抑制HIV‐1感染。 |
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Griffith, E.C., Su, Z., Niwayama, S., et al.Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2Proc. Natl. Acad. Sci. USA95(26),15183-15188(1998)
Kusaka, M., Sudo, K., Fujita, T., et al.Potent anti-angiogenic action of AGM-1470: Comparison to the fumagillin parentBiochem. Biophys. Res. Commun.174(3),1070-1076(1991)
Shadduck, J.A.Effect of fumagillin on in vitro multiplication of Encephalitozoon cuniculiJ. Protozool.27(2),202-208(1980)
Sheen, I.S., Jeng, K.S., Jeng, W.J., et al.Fumagillin treatment of hepatocellular carcinoma in rats: An in vivo study of antiangiogenesisWorld J. Gastroenterol.11(6),771-777(2005)
Lijnen, H.R., Frederix, L., and Van Hoef, B.Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesityObesity18(2),2241-2246(2010)
