Zerumbone
Cat. No.：YN251738
CAS No. ：471-05-6
| 产品名称: | Zerumbone |
| CAS No.: | 471-05-6 |
| Chemical Name: | (2E,6E)-2,6,9,9-tetramethyl-2,6,10E-cycloundecatrien-1-one |
| Synonyms: | 球姜酮 |
| 分子量: | 218.33 |
| 分子式: | C₁₅H₂₂O |
| SMILES: | C/C1=C\CC/C(C)=C/CC(C)(C)/C=C/C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离出来的单环倍半萜烯化合物。Zerumbone 有效抑制Epstein-Barr 病毒的激活，IC50为 0.14 mM。Zerumbone 具有抗癌，抗氧化，抗炎，抗增殖的作用。 |
| IC50和靶点: | |
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Murakami, A., Takahashi, M., Jiwajinda, S., et al.Identification of zerumbone in Zingiber zerumbet smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activationBiosci. Biotechnol. Biochem.63(10),1811-1812(1999)
Murakami, A., Takahashi, D., Kinoshita, T., et al.Zerumbone, a southeast asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The α,β-unsaturated carbonyl group is a prerequisiteCarcinogenesis23(5),795-802(2002)
Stanton, B.Z., and Peng, L.F.Small-molecule modulators of the Sonic Hedgehog signaling pathwayMol. Biosyst.6(1),44-54(2010)
Sun, Y., Sheng, Q., Cheng, Y., et al.Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathwayPharmazie68(2),141-145(2013)
Sehrawat, A., Arlotti, J.A., Murakami, A., et al.Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivoBreast Cancer Res. Treat.136(2),429-441(2012)
Rahman, H.S., Rasedee, A., How, C.W., et al.Zerumbone-loaded nanostructured lipid carriers: Preparation, characterization, and antileukemic effectInt. J. Nanomedicine8,2769-2781(2013)
