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GDC-0152

Cat. No.：873652-48-3

  • CAS No. ：873652-48-3

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    • 产品名称: GDC-0152
      CAS No.: 873652-48-3
      Chemical Name:
      Synonyms:GDC0152
      分子量:498.64
      分子式:C₂₅H₃₄N₆O₃S
      SMILES:O=C(N1[C@H](C(NC2=C(C3=CC=CC=C3)N=NS2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Goyal, L.Cell death inhibition:Keeping caspases in checkCell104,805-808(2001)', 'Flygare, J.A., Beresini, M., Budha, N., et al.Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)J. Med. Chem.55(9),4101-4113(2012)', 'Hu, R., Li, J., Liu, Z., et al.GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K/Akt signaling pathwayTumour Biol.36(2),577-584(2015)', 'Erickson, R.I., Tarrant, J., Cain, G., et al.Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacologyToxicol. Sci.131(1),247-258(2013)
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