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Agmatine sulfate

Cat. No.:YN320116

  • CAS No. :2482-00-0

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    • 产品名称: Agmatine sulfate
      CAS No.: 2482-00-0
      Chemical Name: N-(4-aminobutyl)-guanidine, monosulfate
      Synonyms:Agmatine sulfate salt,硫酸胍基丁胺
      分子量:228.27
      分子式:C₅H₁₆N₄O₄S
      SMILES:NC(NCCCCN)=N.O=S(O)(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Agmatine sulfate在多个靶点上发挥调节作用,如神经递质系统,离子通道,一氧化氮合成。它是imidazoline receptor的内源性激动剂和NO synthase抑制剂。
      IC50和靶点:
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      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Reis, D.J., and Regunathan, S.Is agmatine a novel neurotransmitter in brain?Trends Pharmacol. Sci.21(5),187-193(2000)

      Piletz, J.E.Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and α-2 adrenergic receptorsJ. Pharmacol. Exp. Ther.272(2),581-587(1995)

      Yang, X.C., and Reis, D.J.Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neuronsJ. Pharmacol. Exp. Ther.288(2),544-549(1999)

      Loring, R.H.Agmatine acts as an antagonist of neuronal nicotinic receptorsBr. J. Pharmacol.99(1),207-211(1990)

      Molderings, G.J., Schmidt, K., Bönisch, H., et al.Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of σ2 binding sitesNaunyn Schmiedebergs Arch. Pharmacol.345(3),245-252(1996)

      Shepherd, R.M., Hashmi, M.N., Kane, C., et al.Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin releaseBr. J. Pharmacol.119(5),911-916(1996)

      Demady, D.R., Jianmongkol, S., Vuletich, J.L., et al.Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzymeMol. Pharmacol.59(1),24-29(2001)

      Kolesnikov, Y., Jain, S., and Pasternak, G.W.Modulation of opioid analgesia by agmatineEur. J. Pharmacol.296(1),17-22(1996)

      Schwartz, D., Peterson, O.W., Mendonca, M., et al.Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanismAm. J. Physiol.272(5 Pt 2),F597-F601(1997)

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