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Lifitegrast

Cat. No.：1025967-78-5

  • CAS No. ：1025967-78-5

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    • 产品名称: Lifitegrast
      CAS No.: 1025967-78-5
      Chemical Name:
      Synonyms:立他司特; SAR 1118; SHP-606
      分子量:615.48
      分子式:C₂₉H₂₄Cl₂N₂O₇S
      SMILES:O=C(O)[C@H](CC1=CC=CC(S(=O)(C)=O)=C1)NC(C2=C(Cl)C3=C(CN(C(C4=CC=C5C=COC5=C4)=O)CC3)C=C2Cl)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Zhong, M., Gadek, T.R., Bui, M., et al.Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eyeACS Med. Chem. Lett.3(3),203-206(2012)', 'Semba, C.P., and Gadek, T.R.Development of lifitegrast: A novel T-cell inhibitor for the treatment of dry eye diseaseClin. Ophthalmol.10,1083-1094(2016)', 'Murphy, C.J., Bentley, E., Miller, P.E., et al.The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogsInvest. Opthalmol. Vis. Sci.52(6),3174-3180(2011)', 'Sun, Y., Zhang, R., Gadek, T.R., et al.Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)J. Ocul. Pharmacol. Ther.29(4),395-402(2013)
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