A-205804
Cat. No.：YN300001
CAS No. ：251992-66-2
| 产品名称: | A-205804 |
| CAS No.: | 251992-66-2 |
| Chemical Name: | 4-[(4-methylphenyl)thio]-thieno[2,3-c]pyridine-2-carboxamide |
| Synonyms: | A205804,A 205804,A-205804 |
| 分子量: | 300.40 |
| 分子式: | C₁₅H₁₂N₂OS₂ |
| SMILES: | O=C(C(S1)=CC2=C1C=NC=C2SC3=CC=C(C)C=C3)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-205804 是抑制E-selectin和ICAM-1表达的口服有效的，高效、选择性的先导抑制剂，对 E-selectin 和 ICAM-1 作用的IC50分别为 20 nM 和 25 nM。A-205804 可用于慢性炎症疾病的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Stewart, A.O., Bhatia, P.A., McCarty, C.M., et al.Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expressionJ. Med. Chem.44(6),988-1002(2001)
