Cyclo(-RGDfK)
Cat. No.：YN300064
CAS No. ：161552-03-0
| 产品名称: | Cyclo(-RGDfK) |
| CAS No.: | 161552-03-0 |
| Chemical Name: | cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl) |
| Synonyms: | Cyclo (-RGDfK) |
| 分子量: | 603.67 |
| 分子式: | C₂₇H₄₁N₉O₇ |
| SMILES: | O=C([C@H](CCCCN)NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC(CN2)=O)=O)=O)N[C@@H](CCCNC(N)=N)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cyclo(-RGDfK) 是有效，选择性的整合素αvβ3抑制剂，其 IC50值为 0.94 nM。Cyclo(-RGDfK) TFA 通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。 |
| IC50和靶点: | [{name:"αvβ3:0.94 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Šimeček, J., Notni, J., Kapp, T.G., et al.Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of 68Ga-NOPO-c(RGDfK)Mol. Pharm.11(5),1687-1695(2014)
Dijkgraaf, I., Beer, A.J., and Wester, H.-J.Application of RGD-containing peptides as imaging probes for alphavbeta3 expressionFront. Biosci. (Landmark Ed.)14(3),887-899(2009)
Janssen, M., Oyen, W.J.G., Massuger, L.F.A.G., et al.Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targetingCancer Biother. Radiopharm.17(6),641-646(2002)
