GLPG0187
Cat. No.：YN300002
CAS No. ：1320346-97-1
| 产品名称: | GLPG0187 |
| CAS No.: | 1320346-97-1 |
| Chemical Name: | 3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine |
| Synonyms: | GLPG 0187,GLPG-0187 |
| 分子量: | 595.71 |
| 分子式: | C₂₉H₃₇N₇O₅S |
| SMILES: | O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC=C(OC)C=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GLPG0187是广谱的integrin受体拮抗剂，具有抗肿瘤活性；抑制αvβ1-integrin的IC50值为1.3 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
van der Horst, G., van den Hoogen, C., Buijis, J.T., et al.Targeting of αν-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancerNeoplasia13(6),516-525(2011)
Silginer, M., Weller, M., Ziegler, U., et al.Integrin inhibition promotes atypical anoikis in glioma cellsCell Death Dis.5,e1012(2014)
