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Arg-Gly-Asp-Ser

Cat. No.:YN300024

  • CAS No. :91037-65-9

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    • 产品名称: Arg-Gly-Asp-Ser
      CAS No.: 91037-65-9
      Chemical Name: L-arginylglycyl-L-α-aspartyl-L-serine
      Synonyms:RGDS peptide; Fibronectin tetrapeptide
      分子量:433.42
      分子式:C₁₅H₂₇N₇O₈
      SMILES:O=C(N[C@@H](CO)C(O)=O)[C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Arg-Gly-Asp-Ser是整联蛋白结合序列,抑制整联蛋白受体功能,通过抑制胶原蛋白引发的白细胞活化减少全身炎症,并减弱炎性细胞因子,iNOS和MMP-9的表达。
      IC50和靶点:
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    • Ruoslahti, E., and Öbrink, B.Common principles in cell adhesionExp. Cell Res.227(1),1-11(1996)

      Stömblad, S., and Cheresh, D.A.Integrins, angiogenesis and vascular cell survivalChem. Biol.3(11),881-885(1996)

      Haverstick, D.M., Cowan, J.F., Yamada, K.M., et al.Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectinBlood66(4),946-952(1985)

      Pierschbacher, M.D., and Ruoslahti, E.Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeNature309(5963),30-33(1984)

      Basani, R.B., D'Andrea, G., Mitra, N., et al.RGD-containing peptides inhibit fibrinogen binding to platelet αIIbβ3 by inducing an allosteric change in the amino-terminal portion of αIIbJ. Biol. Chem.276(17),13975-13981(2014)

      Pottratz, S.T., and Martin, W.J., IIMechanism of Pneumocystis carinii attachment to cultured rat alveolar macrophagesJ. Clin. Invest.86(5),1678-1683(1990)

      Thomas, D.D., Baseman, J.B., and Alderete, J.F.Fibronectin tetrapeptide is target for syphilis spirochete cytadherenceJ. Exp. Med.162(5),1715-1719(1985)

      Gartner, T.K., and Bennett, J.S.The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated plateletsJ. Biol. Chem.260(22),11891-11894(1985)

      Ginsberg, M., Pierschbacher, M.D., Ruoslahti, E., et al.Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesionJ. Biol. Chem.260(7),3931-3936(1985)

      Dekkers, B.G.J., Bos, I.S.T., Gosens, R., et al.The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthmaAm. J. Respir. Crit. Care Med.181(6),556-565(2010)

      Moon, C., Han, J.R., Park, H.J., et al.Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathwaysRespir. Res.10(1),18(2009)

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