MK-0429
Cat. No.：YN300038
CAS No. ：227963-15-7
| 产品名称: | MK-0429 |
| CAS No.: | 227963-15-7 |
| Chemical Name: | |
| Synonyms: | L-000845704 |
| 分子量: | 439.51 |
| 分子式: | C₂₃H₂₉N₅O₄ |
| SMILES: | O=C1N([C@H](C2=CC=C(OC)N=C2)CC(O)=O)CCN1CCCC3=NC4=C(C=C3)CCCN4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-0429 (L-000845704) 是可口服，高效，选择性，非多肽整合素泛拮抗剂，对αvβ1、αvβ3、αvβ5、αvβ6、αvβ8 和 α5β1 的IC5 0值分别为1.6 nM、2.8 nM、0.1 nM、0.7 nM、0.5 nM 和 12.2 nM。 |
| IC50和靶点: | [{name:"αvβ1:1.6 nM (IC50, inhibition of fibronectin-binding )"},{name: "αvβ3:2.8 nM (IC50, inhibition of vitronectin-binding)"},{name: "αvβ5:0.1 nM (IC50, inhibition of vitronectin-binding)"},{name: "αvβ6:0.7 nM (IC50, inhibition of LAP-binding)"},{name: "αvβ8:0.5 nM (IC50, inhibition of LAP-binding)"},{name: "α5β1:12.2 nM (IC50, inhibition of fibronectin-binding)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
