SB-743921
Cat. No.：YN290172
CAS No. ：940929-33-9
| 产品名称: | SB-743921 |
| CAS No.: | 940929-33-9 |
| Chemical Name: | N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-benzamide, monohydrochloride |
| Synonyms: | SB743921 HCl,SB743921 |
| 分子量: | 553.52 |
| 分子式: | C₃₁H₃₄Cl₂N₂O₃ |
| SMILES: | ClC1=CC2=C(C(C(CC3=CC=CC=C3)=C([C@@H](C(C)C)N(C(C4=CC=C(C=C4)C)=O)CCCN)O2)=O)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-743921 是一种有效的驱动蛋白 (Eg5) 抑制剂，Ki值为 0.1 nM。 |
| IC50和靶点: | [{name:"Eg5:0.1 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Good, J.A.D., Wang, F., Rath, O., et al.Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft modelsJ. Med. Chem.56(5),1878-1893(2015)
Jackson, J.R., Gilmartin, A., Dhanak, D., et al.Abstract B11: A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancerClin. Cancer Res.12(19 Suppl),(2006)
Bongero, D., Paoluzzi, L., Marchi, E., et al.The novel kinesin spindle protein (KSP) inhibitor SB-743921 exhibits marked activity in in vivo and in vitro models of aggressive large B-cell lymphomaLeuk. Lymphoma56(10),2945-2952(2015)
