JH-II-127
Cat. No.：YN280095
CAS No. ：1700693-08-8
规格
价格(RMB)
库存
| 产品名称: | JH-II-127 |
| CAS No.: | 1700693-08-8 |
| Chemical Name: | [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone |
| Synonyms: | JH-II-127;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloranyl-4-(Methylamino)-7~{h}-Pyrrolo[2,3-D]pyrimidin-2-Yl]amino]-3-Methoxy-Phenyl]-Morpholin-4-Yl-Methanone;BCP16207;SB19025;AK4 |
| 分子量: | 416.86 |
| 分子式: | C₁₉H₂₁ClN₆O₃ |
| SMILES: | O=C(C1=CC=C(NC2=NC3=NC=C(Cl)C3=C(NC)N2)C(OC)=C1)N4CCOCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JH-II-127是一种高效的选择性, 脑渗透性LRRK2 抑制剂, 抑制LRRK2野生型, LRRK2-G2019S,和 LRRK2-A2016T, IC50 值分别为6.6 nM, 2.2 nM ,47.7 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hatcher, J.M., Zhang, J., Choi, H.G., et al.Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitorACS Med. Chem. Lett.6(5),584-589(2015)
