PF-06260933
Cat. No.：YN350196
CAS No. ：1811510-56-1
| 产品名称: | PF-06260933 |
| CAS No.: | 1811510-56-1 |
| Chemical Name: | 5-(4-chlorophenyl)-3,3′-bipyridine]-6,6′-diamine |
| Synonyms: | PF-6260933,PF6260933,PF 6260933 |
| 分子量: | 296.75 |
| 分子式: | C₁₆H₁₃ClN₄ |
| SMILES: | NC1=C(C2=CC=C(Cl)C=C2)C=C(C(C=N3)=CC=C3N)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-06260933 是一种具有口服活性的，高度选择性的MAP4K4小分子抑制剂，在激酶实验和细胞实验中的IC50值分别为 3.7 和 160 nM。 |
| IC50和靶点: | [{name:"MAP4K4:3.7 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ammirati, M., Bagley, S.W., Bhattacharya, S.K., et al.Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatmentACS Med. Chem. Lett.6(11),1128-1133(2015)
Strang, B.L., Asquith, C.R.M., Moshrif, H.F., et al.Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening dataPLoS One13(7),e0201321(2018)
Nam, G.S., Kim, S., Kwon, Y.-S., et al.A new function for MAP4K4 inhibitors during platelet aggregation and platelet-mediated clot retractionBiochem. Pharmacol.188,114519(2021)
Roth Flach, R.J., Skoura, A., Matevossian, A., et al.Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosisNat. Commun.6,8995(2015)
