CGP 57380
Cat. No.：YN350043
CAS No. ：522629-08-9
| 产品名称: | CGP 57380 |
| CAS No.: | 522629-08-9 |
| Chemical Name: | N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
| Synonyms: | MNK1 Inhibitor,N3-(4-氟苯基)-1H-吡唑并[3,4-D]嘧啶-3,4-二胺 |
| 分子量: | 244.23 |
| 分子式: | C₁₁H₉FN₆ |
| SMILES: | NC1=NC=NC2=C1C(NC3=CC=C(F)C=C3)N=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGP 57380 是一种细胞渗透的吡唑-嘧啶类化合物，为具有选择性的Mnk1抑制剂，IC50值为 2.2 μM，但是对 p38，JNK1，ERK1/2，PKC 或 Src-like 激酶等没有抑制作用。 |
| IC50和靶点: | [{name:"MNK1:2.2 μM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Knauf, U., Tschopp, C., and Gram, H.Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2Mol. Cell. Biol.21(16),5500-5511(2001)
Rowlett, R.M., Chrestensen, C.A., Nyce, M., et al.MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophagesAm. J. Physiol. Gastrointest. Liver Physiol.294,452-459(2008)
