Ramelteon

Cat. No.：YN321325

CAS No. ：196597-26-9

产品名称:	Ramelteon
CAS No.:	196597-26-9
Chemical Name:	N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]-propanamide
Synonyms:	雷美替胺; TAK-375
分子量:	259.34
分子式:	C₁₆H₂₁NO₂
SMILES:	O=C(NCC[C@H]1C2=C(C=CC3=C2CCO3)CC1)CC
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	Ramelteon是高效选择性的melatonin受体激动剂，结合人melatonin1和melatonin2受体的Ki值分别为14 和112 pM。
IC50和靶点:
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Kato, K., Hirai, K., Nishiyama, K., et al.Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonistNeuropharmacology48(2),301-310(2005)
Yukuhiro, N., Kimura, H., Nishikawa, H., et al.Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeysBrain Res.1027(1-2),59-66(2004)
Hirai, K., Kita, M., Ohta, H., et al.Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in ratsJ. Biol. Rhythms20(1),27-37(2005)