PIN1 inhibitor API-1
Cat. No.：YN310142
CAS No. ：680622-70-2
| 产品名称: | PIN1 inhibitor API-1 |
| CAS No.: | 680622-70-2 |
| Chemical Name: | N-[4-(2-Amino-9H-purin-6-yloxymethyl)-benzyl]-2,2,2-trifluoroacetamide; PIN1 Inhibitor API-1 |
| Synonyms: | Pin1 inhibitor API-1 |
| 分子量: | 366.30 |
| 分子式: | C₁₅H₁₃F₃N₆O₂ |
| SMILES: | O=C(NCC1=CC=C(COC2=C3NC=NC3=NC(N)=N2)C=C1)C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIN1 inhibitor API-1 是一种特殊的Pin1(peptidyl-prolylcis-transisomerase NIMA-interacting 1) 抑制剂 (API-1)，IC50为 72.3 nM。PIN1 inhibitor API-1 直接特异性地与 Pin1 肽基脯氨酰异构酶 (PPIase) 结构域结合，并抑制 Pin1 顺反异构活性。PIN1 inhibitor API-1 保留 pXPO5 的活性构象，恢复 pXPO5 将前 miRNA 从细胞核转运到细胞质的能力，从 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pu, W., et al.: Hepatology, 68, 547 (2018)
