Danicamtiv
Cat. No.：YN300015
CAS No. ：1970972-74-7
| 产品名称: | Danicamtiv |
| CAS No.: | 1970972-74-7 |
| Chemical Name: | 4-[(1R)-1-[[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]sulfonyl]-1-fluoroethyl]-N-3-isoxazolyl-1-piperidinecarboxamide |
| Synonyms: | SAR 440181 |
| 分子量: | 435.42 |
| 分子式: | C₁₆H₂₀F₃N₅O₄S |
| SMILES: | O=S([C@@](C1CCN(CC1)C(NC2=NOC=C2)=O)(C)F)(C3=CN(N=C3C(F)F)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Danicamtiv，一种肌力剂，是心脏肌动蛋白 (cardiac myosin) 的选择性变构活化剂。Danicamtiv 增加心脏的收缩功能并保持机械效率。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Voors, A.A., Tamby, J.-F., Cleland, J.G., et al.Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trialEur. J. Heart Fail.22(9),1649-1658(2020)
Grillo, M.P., Markova, S., Evanchik, M., et al.Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathyXenobiotica51(2),222-238(2021)
