CGP37157
Cat. No.：YN360563
CAS No. ：75450-34-9
| 产品名称: | CGP37157 |
| CAS No.: | 75450-34-9 |
| Chemical Name: | 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one |
| Synonyms: | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one |
| 分子量: | 324.22 |
| 分子式: | C₁₅H₁₁Cl₂NOS |
| SMILES: | O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3Cl)SC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGP37157 是一种Na+/Ca2+exchanger抑制剂，可抑制豚鼠心脏线粒体 Na+诱导的 Ca2+的释放，IC50值为 0.8 μM。 |
| IC50和靶点: | |
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Cox, D.A., Conforti, L., Sperelakis, N., et al.Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157J. Biomed. Sci.21(4),595-599(1993)
Baron, K.T., and Thayer, S.A.CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neuronsEur. J. Pharmacol.340(2-3),295-300(1997)
White, R.J., and Reynolds, I.J.Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neuronesJ. Physiol.498(Pt 1),31-47(1997)
Palty, R., Silverman, W.F., Hershfinkel, M., et al.NCLX is an essential component of mitochondrial Na+/Ca2+ exchangeProc. Natl. Acad. Sci. USA107(1),436-441(2010)
Parnis, J., Montana, V., Delgado-Martinez, I., et al.Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytesJ. Neurosci.33(17),7206-7219(2013)
