Tegafur
Cat. No.：YN290413
CAS No. ：17902-23-7
规格
价格(RMB)
库存
| 产品名称: | Tegafur |
| CAS No.: | 17902-23-7 |
| Chemical Name: | 5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | 替加氟; FT 207; NSC 148958 |
| 分子量: | 200.17 |
| 分子式: | C₈H₉FN₂O₃ |
| SMILES: | O=C1NC(C(F)=CN1C2OCCC2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tegafur (FT 207; NSC 148958) 是抗癌剂5-FU的前药。 |
| IC50和靶点: | |
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El Sayed, Y.M., and Sadée, W.Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymesCancer Res.43(9),4039-4044(1983)
Engel, D., Nudelman, A., Tarasenko, N., et al.Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic propertiesJ. Med. Chem.51(2),314-323(2008)
Hanada, M., Noguchi, T., and Yamaoka, T.Amrubicin, a novel 9-aminoanthracycline, enhances the antitumor activity of chemotherapeutic agents against human cancer cells in vitro and in vivoCancer Sci.98(3),447-454(2007)
