BX517
Cat. No.:YN420184
产品名称: | BX517 |
CAS No.: | 850717-64-5 |
Chemical Name: | N-[2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-urea |
Synonyms: | BX 517,BX-517,PDK1 inhibitor 2 |
分子量: | 282.30 |
分子式: | C₁₅H₁₄N₄O₂ |
SMILES: | NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | BX517 是一种有效的,选择性的PDK1抑制剂,IC50值为 6 nM。 |
IC50和靶点: | |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Islam, I., Bryant, J., Chou, Y.-L., et al.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activityBioorg. Med. Chem. Lett.17(14),3814-3818(2007)
Islam, I., Brown, G., Bryant, J., et al.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517Bioorg. Med. Chem. Lett.17(14),3819-3825(2007)