GW843682X
Cat. No.：YN290094
CAS No. ：660868-91-7
规格
价格(RMB)
库存
| 产品名称: | GW843682X |
| CAS No.: | 660868-91-7 |
| Chemical Name: | 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide |
| Synonyms: | GW843682 |
| 分子量: | 477.46 |
| 分子式: | C₂₂H₁₈F₃N₃O₄S |
| SMILES: | O=C(C1=C(OCC2=CC=CC=C2C(F)(F)F)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW843682X 是一种选择性的，ATP-竞争性的PLK1andPLK3抑制剂，IC50值分别为 2.2 nM and 9.1 nM，选择性是其他 30 种激酶的 100 多倍。 |
| IC50和靶点: | [{name:"PLK1:2.2 nM (IC50)"},{name: "PLK3:9.1 nM (IC50)"},{name: "PDGFR1β:160 nM (IC50)"},{name: "VEGFR2:360 nM (IC50)"},{name: "Aurora A:4800 nM (IC50)"},{name: "CDK2/cyclin A:7600 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lansing, T.J., McConnell, R.T., Duckett, D.R., et al.In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1Mol. Cancer Ther.6(2),450-459(2007)
Ikezoe, T., Yang, J., Nishioka, C., et al.A novel treatment strategy targeting polo-like kinase 1 in hematological malignanciesLeukemia23(9),1564-1574(2009)
