TGN-020
Cat. No.：YN430403
CAS No. ：51987-99-6
规格
价格(RMB)
库存
| 产品名称: | TGN-020 |
| CAS No.: | 51987-99-6 |
| Chemical Name: | N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide |
| Synonyms: | TGN020 |
| 分子量: | 206.22 |
| 分子式: | C₈H₆N₄OS |
| SMILES: | O=C(C1=CC=CN=C1)NC2=NN=CS2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TGN-020 是一种选择性水通道蛋白 4 (AQP4) 抑制剂，IC50为 3.1 μM。TGN-020 是一种PROTAC linker，属于 alkyl chain 类，可用于合成 PROTAC 分子。TGN-020 减轻大鼠脊髓压迫损伤后的水肿并抑制神经胶质瘢痕的形成。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Huber, V.J., Tsujita, M., and Nakada, T.Identification of aquaporin 4 inhibitors using in vitro and in silico methodsBioorg. Med. Chem.17(1),411-417(2009)
Igarashi, H., Huber, V.J., Tsujita, M., et al.Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edemaNeurol. Sci.32(1),113-116(2011)
Guo, C., Wu, T., Zhu, H., et al.Aquaporin 4 blockade attenuates acute lung injury through inhibition of Th17 cell proliferation in miceInflammation42(4),1401-1412(2019)
