MPEP Hydrochloride
Cat. No.：YN320896
CAS No. ：219911-35-0
规格
价格(RMB)
库存
| 产品名称: | MPEP Hydrochloride |
| CAS No.: | 219911-35-0 |
| Chemical Name: | 2-methyl-6-(2-phenylethynyl)-pyridine, monohydrochloride |
| Synonyms: | |
| 分子量: | 229.70 |
| 分子式: | C₁₄H₁₂ClN |
| SMILES: | CC1=NC(C#CC2=CC=CC=C2)=CC=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MPEP Hydrochloride 是有效的、选择性的、非竞争性的、口服有效的、具有系统活性的mGlu5受体拮抗剂，其完全抑制quisqualate 刺激的磷酸肌醇水解的IC50值为 36 nM。MPEP Hydrochloride 具有抗焦虑或抗抑郁活性。 |
| IC50和靶点: | [{name:"mGluR5:36 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tatarczynska, E., Klodzinska, A., Chojnacka-Wójcik, E., et al.Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonistBr. J. Pharmacol.132(7),1423-1430(2001)
Mathiesen, J.M., Svendsen, N., Bräuner-Osborne, H., et al.Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEPBr. J. Pharmacol.138(6),1026-1030(2003)
