PROTAC Bcl2 degrader-1
Cat. No.：YN430109
CAS No. ：2378801-85-3
规格
价格(RMB)
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| 产品名称: | PROTAC Bcl2 degrader-1 |
| CAS No.: | 2378801-85-3 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 941.84 |
| 分子式: | C₄₅H₄₅BrN₆O₁₀S |
| SMILES: | O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PROTAC Bcl2 degrader-1 (Compound C5) 是一种PROTAC，通过将 E3 连接酶 cereblon 的配体 pomalidomide 引入到 Mcl-1/Bcl-2 的双重抑制剂 Nap-1，来有效、特异性地诱导Bcl-2(IC50，4.94 μM；DC50，3.0 μM) 和Mcl-1(IC50，11.81 μM) 的降解。 |
| IC50和靶点: | [{name:"Bcl-2:3 μM (DC50)"},{name: "Bcl-2:4.94 μM (IC50)"},{name: "Mcl-1:11.81 μM (IC50)"}] |
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| Solvent & Solubility: |
