Borrelidin

Cat. No.：7184-60-3

CAS No. ：7184-60-3

产品名称:	Borrelidin
CAS No.:	7184-60-3
Chemical Name:
Synonyms:	Treponemycin
分子量:	489.64
分子式:	C₂₈H₄₃NO₆
SMILES:	O=C([C@H]1[C@H]([C@H](C/C=C/C=C(C#N)\[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)C2)OC2=O)CCC1)O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Wakabayashi, T., Kageyama, R., Naruse, N., et al.Borrelidin is an angiogenesis inhibitor; Disruption of angiogenic capillary vessels in a rat aorta matrix culture modelJ. Antibiot. (Tokyo)50(8),671-676(1997)', 'Kawamura, T., Liu, D., Towle, M.J., et al.Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: Threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cellsJ. Antibiot. (Tokyo)56(8),709-715(2003)', 'Woolard, J., Vousden, W., Moss, S.J., et al.Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoformsChem. Sci.2011(2),273-278(2011)', 'Paetz, W., and Nass, G.Biochemical and immunological characterization of threonyl-tRNA synthetase of two borrelidin-resistant mutants of Escherichia coli K12Eur. J. Biochem.35(2),331-337(1973)', 'Otoguro, K., Ui, H., Ishiyama, A., et al.In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of PlasmodiaJ. Antibiot. (Tokyo)56(8),727-729(2003)', 'Tsuchiya, E., Yukawa, M., Miyakawa, T., et al.Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiaeJ. Antibiot. (Tokyo)54(1),84-90(2001)